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Speaker: Dr. Alba Simats Oriol, MSCA postdoctoral researcher at Institute of Biomedical Research at the Spanish Research Council (CSIC),
Abstract: Stroke leads to a significant medical burden, not just from brain injury itself but also due to subsequent secondary complications and comorbidities. By exploring the systemic immunological consequences of stroke, we found that myeloid innate immune memory contributes to secondary peripheral organ dysfunction after stroke. Using single-cell sequencing, we observed persistent pro-inflammatory changes in resident monocytes/macrophages across multiple peripheral organs up to three months after stroke, which were particularly abundant in the heart and associated with the development of chronic cardiac fibrosis and diastolic dysfunction. We identified IL-1b as the key driver of epigenetic changes contributing to innate immune memory post-stroke. By targeting IL-1â or blocking pro-inflammatory monocyte trafficking, we prevented post-stroke cardiac dysfunction, suggesting potential immune-focused therapies. These findings could offer insights into IL-1â-mediated comorbidities and innate immune reprogramming post-stroke, potentially aiding in understanding and preventing stroke-related health complications.
Host: Dr. Anna Rosell Novel, Head of group, Neurovascular Diseases (VHIR)
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https://gencat.zoom.us/webinar/register/WN_H3qMT24iRf6nsjq3YkCjog
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